Bryan Johnson's Skincare Protocol for 2025

Here is his latest protocol directly from his newsletter! LFG!

We offer all these in our Longevity stack!

 
Here are a few basics to maintain healthy skin:
  • Exercise.
  • Prioritize your sleep.
  • Eat a healthy, Blueprint-like diet.
  • Consider getting sun earlier in the day and later in the evenings when the UV index is lower.
  • Avoid junk, fried, or highly processed foods. Avoid cigarettes and vaping.
  • The sun is good for you but not too much and not too little. Just the right amount will do.
  • If you’re getting direct sun exposure when the UV index is high (10 am - 4 pm), you can protect your skin with options such as clothing, a UV umbrella, a hat, and mineral sunscreen.
My daily protocol:
  • Face wash morning and night.
  • Sunscreen (mineral).
  • Moisturize (body and face).
  • Targeted Treatments: Use products containing the following active ingredients:
    + Niacinamide (morning and night) found in serums or moisturizers.
    + Vitamin C (morning) typically in a serum.
    + Hyaluronic acid (as desired) – usually in a serum or moisturizer.
    + Tretinoin (prescription, at night).
Avoid endocrine disruptors in skincare products:

Endocrine disruptors, such as parabens, phthalates, and parfum, are natural or man-made chemicals that may mimic or interfere with the body’s hormones, known as the endocrine system. These chemicals are linked with many health problems in both wildlife and humans.
 
Next, here are some supplements to support skin health:
  • Collagen (20-30g daily): Pair with Vitamin C to boost collagen synthesis.
  • Niacinamide
  • Hyaluronic acid 
 Here are some pro tips:
  • UV-tinted windows to block 99% of damaging UV rays.
  • A UV umbrella during high UV index times.
  • Microdosing Accutane (40 mg weekly) for blemish-free skin. Alternatives include over-the-counter retinols.
  • Red light therapy 3x per week.
Note: If you don’t have easy access to red light therapy, don’t worry. The basics are a great place to start.
 
To track my progress, we routinely measure the biological age of my skin using multispectral imaging (in the U.S., Visia is a popular choice).

It provides detailed views of skin health, including:
  • UV damage.
  • Pore size.
  • Dark spots.
  • And many other indicators.
Some wellness clinics offer this service. You can search locally to find one.
 
There are a few advanced therapies I've been experimenting with to target collagen production, skin firmness, and overall skin health:
  • Tixel for improved collagen and elastin.
  • Sofwave for improved collagen and elastin.
  • Sculptra to boost natural collagen production (injected in the face).
Finally, at Blueprint we are working on some exciting new products to cover all of your skincare requirements. We are developing a cleanser, serum, moisturizer, and SPF that will launch later this year.
 
I’m excited to be on this journey with you.
 
Be well,
 
Bryan
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